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AIDS is a life threatening, painful disease with no current vaccine or cure. Asepsis is a condition in which no living disease-causing microorganisms are present. Healthcare professionals use aseptic technique to protect patients from infection. The medical community define clean technique as a modified form of aseptic technique, as maintaining proper hygiene and a clean environment will help achieve asepsis. Healthcare workers must sterilize equipment before procedures. The two types of asepsis are medical asepsis and surgical asepsis. Citation: Denton A, Hallam C (2020) Principles of asepsis 1: the rationale for using aseptic technique. Loveday HP et al (2014) epic3: National evidence-based guidelines for preventing healthcare associated infections in NHS hospitals. In many cases, individual suffer these infections in medical settings, especially when they receive injections, catheters, or surgery. It is possible that some of these reasons to get a blood transfusion could be avoided if one has a healthy lifestyle, practices proper nutrition, exercises and practices stress relieving techniques. Asepsis covers all those procedures designed to reduce the risk of bacterial, fungal or viral contamination, using sterile instruments, sterile draping and the gloved ‘no touch' technique. If a sterile dressing pack is being used, care should be taken to ensure that only the corners are used when opening out the sterile field. Keywords: asepsis, antisepsis, cosmetology, treatment system of healthcare facilities, cosmetic procedures and agents. Rigid adherence to aseptic procedures is the only way to ensure that a patient is at minimal risk for infection. The most commonly occurring pathogenic microorganisms that lead to healthcare-acquired infections are , staphylococcus aureus, pseudomonas aeruginosa, candida albicans, and enterococcus. Sterile liquids must be poured carefully into sterile containers on the sterile field without the solution running over and obliterating the label on the bottle. Health care workers have to care for their COVID-19 patients within very close distances for prolonged periods of time. It is the doyen retractor responsibility of health care to report communicable diseases and not the responsibility of the client or the family member. This led the medical community to stop relying solely on antiseptic techniques and emphasize asepsis as well. Non-touch practices prohibit healthcare professionals from touching key parts of objects, such as syringe tips and the inside of sterile dressings, even when they are wearing gloves. It could be suggested that understanding the principles of asepsis goes back as far as Florence Nightingale, who made the links between good hand hygiene and reduction in wound infections in 1855 (Rowley et al, 2010). They will use aseptic technique during surgical operations or when inserting a foreign object, such as a catheter, into a person's body.