Användare:RemonaMarsh0131

Theophylline is predominantly metabolized by cytochrome P4501A2 (CYP1A2). A doable interplay between griseofulvin and Fuxilidin generisch theophylline was reported to our laboratory, which led us to type the speculation that griseofulvin induces the metabolism of theophylline. One goal of this study was to research this hypothesis. The study was carried out as a randomized crossover examine of 12 healthy volunteers. In interval A of the study, each volunteer received a single dose of 300 mg theophylline ethylenediamine orally. In period B, the subjects took fluvoxamine, 50 mg for acheter Atorlip-20 en ligne 1 day and 100 mg for generico Flucostat 6 days, and milclick.com on day 4, the topics ingested 300 mg theophylline ethylenediamine. Fluvoxamine is a potent inhibitor pharmacies shipping to usa of CYP1A2, and period B was included as a positive control. In period C, milclick.com the topics took 500 mg griseofulvin for 9 days; on day eight the topics again ingested 300 mg theophylline ethylenediamine. During fluvoxamine intake, the median of the whole clearance of theophylline decreased from 80 ml/min to 24 ml/min, and the half-life increased from 6.6 to 22 h. Theophylline